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Jacobus Hendrik Müller, Ph.D.


Department of Engineering
Mechanical Engineering

Education

Ph.D. in Mechanical Engineering (Stellenbosch University, South Africa)
Doctoral Dissertation: Modelling subject-specific patellofemoral joint dynamics
M.Sc.Eng in Mechanical Engineering (Stellenbosch University, South Africa)
B.Eng. in Mechanical Engineering (Stellenbosch University, South Africa)

Practice Areas

I began my career as a senior lecturer in mechanical engineering at Stellenbosch University (South Africa), specializing in knee biomechanics. For nearly a decade, I taught and conducted research in computational modeling and orthopedic biomechanics. In 2019, I transitioned to clinical research, joining ReSurg (Spain) to apply my engineering expertise to study design, statistical analysis, and medical writing. Collaborations with clinicians and industry led to numerous PubMed-indexed publications. Building on this experience, I co-founded ProSurg (France) in 2024, an international Clinical Research Organization (CRO) providing tailored research solutions for medical device companies, healthcare professionals, and scientific societies.

Publications and Media Placements

Stöve, J., et al., No difference in PROMs between kinematic and mechanical alignment in TKA: An umbrella review with secondary meta-analysis and GRADE assessment. Knee Surgery, Sports Traumatology, Arthroscopy, 2025.

Schrednitzki, D., et al., Increased prevalence of tibiofemoral noises in posterior-stabilised implants compared to cruciate-retaining and ultracongruent implants in total knee arthroplasty: A systematic review and meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 2025.

Sappey-Marinier, E., et al., Patient-reported outcome measures following individualised TKA are not affected by the degree of preoperative coronal varus or valgus laxity. Knee Surgery, Sports Traumatology, Arthroscopy, 2025. 33(4): p. 1358-1370.

Saffarini, M., et al., Sparse and inconsistent reporting of pre- and post-operative radiographic angles of total knee arthroplasty using true unrestricted kinematic alignment: An umbrella review and secondary meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 2025. 33(3): p. 997-1014.

Marchetti, E., et al., Augmented reality navigation improves intraoperative resection accuracy but may not prevent alignment deviations in total knee arthroplasty. Journal of Experimental Orthopaedics, 2025. 12(4).

Dejour, D.H., et al., Standardized magnetic resonance image-based assessment to define functional patella alta relative to both tibia and trochlea: A cross-sectional comparative study. Knee Surgery, Sports Traumatology, Arthroscopy, 2025.

Dejour, D.H., et al., Adapting the Dejour classification of trochlear dysplasia from qualitative radiograph- and CT-based assessments to quantitative MRI-based measurements. Knee Surgery, Sports Traumatology, Arthroscopy, 2025. 33(8): p. 2833-2846.

Dejour, D., et al., Sulcus-deepening trochleoplasty grants satisfactory results with minimal patellofemoral arthritis at 23–30 years of follow-up. Knee Surgery, Sports Traumatology, Arthroscopy, 2025. 33(1): p. 79-85.

Cognault, J., et al., Inappropriate grouping of various kinematic alignment techniques and inconsistent reporting of adverse events invalidate comparison across studies: An umbrella review of meta-analyses. Knee Surgery, Sports Traumatology, Arthroscopy, 2025. 33(8): p. 2880-2895.

Sappey-Marinier, E., et al., Better operating room efficiency and reduced staff demand: Individualised versus off-the-shelf total knee arthroplasty. Knee Surgery, Sports Traumatology, Arthroscopy, 2024. 32(12): p. 3174-3184.

Jenny, J.Y., et al., Complication Rates Are Not Higher After Outpatient Versus Inpatient Fast-Track Total Knee Arthroplasty: A Propensity-Matched Prospective Comparative Study. Journal of Arthroplasty, 2024. 39(10): p. 2458-2465.

Gallinet, D., et al., Intraoperative repair of functional subscapularis during RSA by deltopectoral approach could improve internal rotation but does not prevent anterior dislocation. Orthopaedics and Traumatology: Surgery and Research, 2024. 110(5).

Demey, G., et al., A Supratuberosity Anterior Closing-Wedge Proximal Tibial Osteotomy Increases Patellar Height: A Simulated Time Zero Uniplanar Radiographic Study. Arthroscopy - Journal of Arthroscopic and Related Surgery, 2024. 40(5): p. 1544-1554.e1.

de Ladoucette, A., et al., Complication rates are not higher after outpatient compared to inpatient fast-track total hip arthroplasty: a propensity-matched prospective comparative study. HIP International, 2024. 34(6): p. 724-732.

Beel, W., et al., Individualised compared to off-the-shelf total knee arthroplasty results in lower and less variable patellar tilt. Knee Surgery, Sports Traumatology, Arthroscopy, 2024. 32(12): p. 3163-3173.

Winnock de Grave, P., et al., Inverse kinematic alignment accommodates native coronal knee alignment better in comparison to adjusted mechanical alignment and restricted kinematic alignment. Knee Surgery, Sports Traumatology, Arthroscopy, 2023. 31(9): p. 3765-3774.

Pineda, T., et al., Inconsistent repeatability of the Dejour classification of trochlear dysplasia due to the variability of imaging modalities: a systematic review. Knee Surgery, Sports Traumatology, Arthroscopy, 2023. 31(12): p. 5707-5720.

Müller, J.H., et al., No significant difference in early clinical outcomes of custom versus off-the-shelf total knee arthroplasty: a systematic review and meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 2023. 31(4): p. 1230-1246.

Luyckx, T., et al., What are the perceived benefits and barriers to the use of robot-assisted total knee arthroplasty? A survey of members of the European Knee Society. International Orthopaedics, 2023. 47(2): p. 405-412.

La Scala, E., et al., Effect of preoperative coronary CT for planning of percutaneous coronary intervention for complex chronic total occlusion (CTS-C-CTOPCI): study protocol for an open-label randomised controlled trial. Trials, 2023. 24(1).

Gousopoulos, L., et al., Custom total knee arthroplasty combined with personalised alignment grants 94% patient satisfaction at minimum follow-up of 2 years. Knee Surgery, Sports Traumatology, Arthroscopy, 2023. 31(4): p. 1276-1283.

Godenèche, A., et al., Reverse shoulder arthroplasty renders better clinical scores at a minimum follow-up of two years for patients with no rotator cuff deficiency operated by the deltopectoral approach. International Orthopaedics, 2023. 47(9): p. 2285-2293.

Ducharne, L., et al., Factors that affect external rotation following reverse shoulder arthroplasty: a retrospective multi-centre study on 501 shoulders. Archives of Orthopaedic and Trauma Surgery, 2023. 143(11): p. 6487-6496.

Dobbelaere, A., et al., Sagittal femoral condylar shape varies along a continuum from spherical to ovoid: a systematic review and meta-analysis. Archives of Orthopaedic and Trauma Surgery, 2023. 143(6): p. 3347-3361.

Demey, G., et al., Sufficient Metaphyseal Bone for Wedge Removal and Fixation Hardware During Supratuberosity Tibial Deflexion Osteotomy in Knees With Excessive Posterior Tibial Slope. American Journal of Sports Medicine, 2023. 51(8): p. 2091-2097.

Daxhelet, J., et al., Custom TKA enables adequate realignment with minimal ligament release and grants satisfactory outcomes in knees that had prior osteotomies or extra-articular fracture sequelae. Knee Surgery, Sports Traumatology, Arthroscopy, 2023. 31(4): p. 1212-1219.

Dandois, F., et al., Sensitivity of Model-Based Predictions of Post-TKA Kinematic Behavior to Residual Errors in Ultrasound-Based Knee Collateral Ligament Strain Assessment. Sensors, 2023. 23(19).

Bonnin, M.P., et al., Arthroscopic popliteal tenotomy grants satisfactory outcomes in total knee arthroplasty with persistent localised posterolateral pain and popliteus tendon impingement. Knee Surgery, Sports Traumatology, Arthroscopy, 2023. 31(8): p. 3291-3298.

Beckers, L., et al., Considerable inter-individual variability of tibial geometric ratios renders bone–implant mismatch unavoidable using off-the-shelf total knee arthroplasty: a systematic review and meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 2023. 31(4): p. 1284-1298.

Authom, T., et al., Mid-Term to Long-Term Follow-Up of Stemless Anatomic Total Shoulder Arthroplasty. Journal of Shoulder and Elbow Arthroplasty, 2023. 7.

Winnock de Grave, P., et al., Higher satisfaction after total knee arthroplasty using restricted inverse kinematic alignment compared to adjusted mechanical alignment. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(2): p. 488-499.

Tandogan, R.N., et al., Computer-assisted surgery and patient-specific instrumentation improve the accuracy of tibial baseplate rotation in total knee arthroplasty compared to conventional instrumentation: a systematic review and meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(8): p. 2654-2665.

Reynolds, R.J., et al., Kinematics of the Native Knee, in Basics in Primary Knee Arthroplasty. 2022. p. 19-42.

Ratano, S., et al., Custom TKA combined with personalised coronal alignment yield improvements that exceed KSS substantial clinical benefits. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(9): p. 2958-2965.

Nourissat, G., et al., Mid- to long-term clinical outcomes after press-fit short stem reverse shoulder arthroplasty. JSES International, 2022. 6(6): p. 896-902.

Kort, N., et al., Robot-assisted knee arthroplasty improves component positioning and alignment, but results are inconclusive on whether it improves clinical scores or reduces complications and revisions: a systematic overview of meta-analyses. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(8): p. 2639-2653.

Demey, G., et al., Insufficient evidence to confirm benefits of custom partial knee arthroplasty: a systematic review. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(12): p. 3968-3982.

Dejour, D.H., et al., Implant survival of 3rd-condyle and post-cam posterior-stabilised total knee arthroplasty are comparable at follow-up > 10 years: a systematic review. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(3): p. 1001-1024.

Butnaru, M., et al., Arthroscopic management of unexplained pain following total knee arthroplasty. Archives of Orthopaedic and Trauma Surgery, 2022. 142(6): p. 1109-1115.

Bull, D., et al., Medial/central PF arthritis and functionally stable ACL deficiency do not compromise outcomes of fixed-bearing medial UKA. Knee, 2022. 35: p. 8-15.

Bonnin, M.P., et al., Correction to: Custom total knee arthroplasty facilitates restoration of constitutional coronal alignment (Knee Surgery, Sports Traumatology, Arthroscopy, (2022), 30, 2, (464-475), 10.1007/s00167-020-06153-8). Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(2): p. 476.

Bonnin, M.P., et al., Custom total knee arthroplasty facilitates restoration of constitutional coronal alignment. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(2): p. 464-475.

Bonnevialle, N., et al., Mechanical behavior of hybrid glenoid components compared to all-PE components: a finite element analysis. Journal of Experimental Orthopaedics, 2022. 9(1).

Bercovy, M., et al., Satisfactory mid- to long-term outcomes of TKA aligned using conventional instrumentation for flexion gap balancing with minimal soft tissue release. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(2): p. 627-637.

Beckers, L., et al., Sexual dimorphism and racial diversity render bone–implant mismatch inevitable after off-the-shelf total knee arthroplasty: a systematic review and meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 2022. 30(3): p. 809-821.

Nogier, A., et al., Outcomes of primary total hip arthroplasty using 3D image-based custom stems in unselected patients: a systematic review. EFORT Open Reviews, 2021. 6(12): p. 1166-1180.

Kort, N., et al., Clinical and surgical outcomes of robot-assisted versus conventional total hip arthroplasty: a systematic overview of meta-analyses. EFORT Open Reviews, 2021. 6(12): p. 1157-1165.

Courage, O., et al., Higher rates of surgical and medical complications and mortality following TKA in patients aged ≥ 80 years: A systematic review of comparative studies. EFORT Open Reviews, 2021. 6(11): p. 1052-1062.

Müller, J.H., et al., Prediction of patellofemoral joint kinematics and contact through co-simulation of rigid body dynamics and nonlinear finite element analysis. Computer Methods in Biomechanics and Biomedical Engineering, 2020. 23(11): p. 718-733.

Müller, J.H., et al., Sexual and ethnic polymorphism result in considerable mismatch between native trochlear geometry and off-the-shelf TKA prostheses. Knee Surgery, Sports Traumatology, Arthroscopy, 2020. 28(12): p. 3871-3878.

Kalache, H., et al., Patient-specific instrumentation does not improve tibial component coronal alignment for medial UKA compared to conventional instrumentation. Journal of Experimental Orthopaedics, 2020. 7(1).

Butnaru, M., et al., Wiberg Type III patellae and J-sign during extension compromise outcomes of total knee arthroplasty without patellar resurfacing. Knee, 2020. 27(3): p. 787-794.

Bonnevialle, N., et al., Effect of RSA glenoid baseplate central fixation on micromotion and bone stress. JSES International, 2020. 4(4): p. 979-986.

Aït-Si-Selmi, T., et al., Patellar facet ratio affects knee pain, stair climbing and stair descent after TKA without patellar resurfacing. Knee Surgery, Sports Traumatology, Arthroscopy, 2020. 28(12): p. 3796-3804.

Rodríguez, R.A., K.H. Dellimore, and J.H. Müller, Evaluating the Performance of Cardiac Pulse Duplicators Through the Concept of Fidelity. Cardiovascular Engineering and Technology, 2019. 10(3): p. 423-436.

Cho, K.J., P.J. Erasmus, and J.H. Müller, Sagittal shapes of current fixed-bearing unicompartmental knee replacements differ from those of normal knees. Knee, 2019. 26(3): p. 759-767.

Saffarini, M., et al., Inadequacy of computed tomography for pre-operative planning of patellofemoral arthroplasty. Knee Surgery, Sports Traumatology, Arthroscopy, 2018. 26(5): p. 1485-1492.

Moses, J., J.H. Müller, and A.F. Doubell. Improving the diagnosis of infective endocarditis: The development of, and safety testing for, a novel blood culture device. in 2018 3rd Biennial South African Biomedical Engineering Conference, SAIBMEC 2018. 2018.

Davis, K., et al. Evaluating the impact of air compliance chamber volumes on valve performance for three different heart valves. in 2018 3rd Biennial South African Biomedical Engineering Conference, SAIBMEC 2018. 2018.

Cockcroft, J., J. Müller, and C. Scheffer, Robust tracking of bicycle crank angles using magneto-inertial sensors, domain constraints and functional frame alignment techniques. Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology, 2018. 232(1): p. 5-14.

Wiesner, F.J., et al., Patellofemoral arthroplasty changes the trochlear groove angle. Journal of Mechanics in Medicine and Biology, 2017. 17(4).

Müller, J.H. and W. van der Merwe, Primary principles in soft tissue balancing, in Soft Tissue Balancing in Total Knee Arthroplasty. 2017. p. 41-48.

Müller, J.H., et al., Computational modelling of mobile bearing TKA anterior–posterior dislocation. Computer Methods in Biomechanics and Biomedical Engineering, 2016. 19(5): p. 549-562.

Cho, K.J., P.J. Erasmus, and J.H. Müller, The effect of axial rotation of the anterior resection plane in patellofemoral arthroplasty. Knee, 2016. 23(5): p. 895-899.

Cockcroft, J., J.H. Müller, and C. Scheffer, A complementary filter for tracking bicycle crank angles using inertial sensors, kinematic constraints, and vertical acceleration updates. IEEE Sensors Journal, 2015. 15(8): p. 4218-4225.

Cho, K.J., J.H. Müller, and P.J. Erasmus. Trochlear groove alignment measurement method for surgical applications. in Journal of Mechanics in Medicine and Biology. 2015.

Müller, J.H., et al. Application of an in-vivo validated lower body musculoskeletal model as a test platform for different total knee prostheses. in 9th South African Conference on Computational and Applied Mechanics, SACAM 2014. 2014.

Müller, J.H., Computational modelling of knee implants, in Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System: Biomaterials and Tissues. 2014. p. 417-446.

Menon, P.G. and J.H. Müller. Characterization of a novel imaging-based metric of patellofemoral separation using computational modeling. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2014.

Cockcroft, J., J.H. Müller, and C. Scheffer, A novel complimentary filter for tracking hip angles during cycling using wireless inertial sensors and dynamic acceleration estimation. IEEE Sensors Journal, 2014. 14(8): p. 2864-2871.

Cho, K.J., et al., Application of an artificial neural network and morphing techniques in the redesign of dysplastic trochlea. Acta of Bioengineering and Biomechanics, 2014. 16(2): p. 75-84.

Müller, J.H. Simulating instrumented knee implant forces with a simplified computational model. in ASME 2013 Summer Bioengineering Conference, SBC 2013. 2013.

Cho, K., et al., Application of an artificial neural network for the quantitative classification of trochlear dysplasia. Journal of Mechanics in Medicine and Biology, 2013. 13(4).

Müller, J.H., P.J. Erasmus, and C. Scheffer, Comparison of commercial patellofemoral arthroplasty systems on the basis of patella kinematics, peri-patellar soft tissue tension and prosthesis design. Journal of Mechanics in Medicine and Biology, 2012. 12(5).

Müller, J.H. Simulating in-vivo tibiofemoral loads with the aid of a customised lifemodeler musculoskeletal system. in ASME 2012 Summer Bioengineering Conference, SBC 2012. 2012.

Müller, J.H., et al. Patella tracking with peripatellar soft tissue stabilizers as a function of dynamic subject-specific knee flexion. in Journal of Mechanics in Medicine and Biology. 2011.

Müller, J.H., et al. Comparison of two commercial patellofemoral prostheses by means of computational modeling. in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010.

Müller, J.H., C. Scheffer, and A. Elvin, In-vivo detection of patellar tendon creep using a fibre-optic sensor. International Journal of Medical Engineering and Informatics, 2008. 1(2): p. 155-173.

Dillon, E.M., et al., Differential forces within the proximal patellar tendon as an explanation for the characteristic lesion of patellar tendinopathy: An in vivo descriptive experimental study. American Journal of Sports Medicine, 2008. 36(11): p. 2119-2127.

Professional Organizations and Associations

Editorial Board Memberships

BMC Musculoskeletal Disorders
Knee Surgery, Sports Traumatology, Arthroscopy